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1

Novel inhibitors of epidermal growth factor receptor: (4-(Arylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl)(1H-indol-2-yl)methanones and (1H-indol-2-yl)(4-(phenylamino)thieno[2,3-d]pyrimidin-6-yl)methanones

Thomas Beckers, Andreas Sellmer, Emerich Eichhorn, Herwig Pongratz, Christoph Schächtele, Frank Totzke, Gerhard Kelter, Rebekka Krumbach, Heinz-Herbert Fiebig, Frank-D. Böhmer, Siavosh Mahboobi

Journal:

Bioorganic & Medicinal Chemistry

Année:

2012

Langue:

english

Fichier:

PDF, 1.30 MB

english, 2012

2

Loss of PTPRJ/DEP-1 enhances NF2/Merlin-dependent meningioma development

Waldt, Natalie, Scharnetzki, David, Kesseler, Christoph, Kirches, Elmar, Stroscher, Nele, Böhmer, Frank-D, Mawrin, Christian

Journal:

Journal of the Neurological Sciences

Année:

2020

Langue:

english

Fichier:

PDF, 1.09 MB

english, 2020

3

Cellular Inhibition of Protein Tyrosine Phosphatase 1B by Uncharged Thioxothiazolidinone Derivatives

Matthew Stuible, Liang Zhao, Isabelle Aubry, Dirk Schmidt-Arras, Frank-D. Böhmer, Chao-Jun Li, Michel L. Tremblay

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 308 KB

english, 2007

4

A polypeptide growth inhibitor isolated from lactating bovine mammary gland (MDGI) is a lipid-carrying protein

Frank-D. Böhmer, Maren Mieth, Gunter Reichmann, Christel Taube, Richard Grosse, Morley D. Hollenberg

Journal:

Journal of Cellular Biochemistry

Année:

1988

Langue:

english

Fichier:

PDF, 379 KB

english, 1988

5

Identification of 3-hydroxy-β-damascone and related carotenoid-derived aroma compounds as novel potent inducers of Nrf2-mediated phase 2 response with concomitant anti-inflammatory activity

Clarissa Gerhäuser, Karin Klimo, Wolfgang Hümmer, Jana Hölzer, Astrid Petermann, Antonio Garreta-Rufas, Frank-D. Böhmer, Peter Schreier

Journal:

Molecular Nutrition & Food Research

Année:

2009

Langue:

english

Fichier:

PDF, 424 KB

english, 2009

6

GSTT2, a phase II gene induced by apple polyphenols, protects colon epithelial cells against genotoxic damage

Astrid Petermann, Claudia Miene, Gabriele Schulz-Raffelt, Katja Palige, Jana Hölzer, Michael Glei, Frank-D. Böhmer

Journal:

Molecular Nutrition & Food Research

Année:

2009

Langue:

english

Fichier:

PDF, 1.83 MB

english, 2009

7

Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones

Siavosh Mahboobi, Andrea Uecker, Christophe Cénac, Andreas Sellmer, Emerich Eichhorn, Sigurd Elz, Frank-D. Böhmer, Stefan Dove

Journal:

Bioorganic & Medicinal Chemistry

Année:

2007

Langue:

english

Fichier:

PDF, 1.07 MB

english, 2007

8

Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides – A SAR study on the bioisosterism of pyrimidine and imidazole

Siavosh Mahboobi, Andreas Sellmer, Asma Eswayah, Sigurd Elz, Andrea Uecker, Frank-D. Böhmer

Journal:

European Journal of Medicinal Chemistry

Année:

2008

Langue:

english

Fichier:

PDF, 464 KB

english, 2008

9

Tricyclic quinoxalines as potent kinase inhibitors of PDGFR kinase, Flt3 and Kit

Aviv Gazit, Kevin Yee, Andrea Uecker, Frank-D Böhmer, Tobias Sjöblom, Arne Östman, Johannes Waltenberger, Gershon Golomb, Shmuel Banai, Michael C Heinrich, Alexander Levitzki

Journal:

Bioorganic & Medicinal Chemistry

Année:

2003

Langue:

english

Fichier:

PDF, 624 KB

english, 2003

10

Regulation of the epididymal receptor tyrosine kinase ros by the protein tyrosine phosphatase SHP-1

Rico Pusch, Annette Böhmer, Christoph Biskup, Klaus Benndorf, Jörg Lindenau, Frank-D. Böhmer

Journal:

American Journal of Reproductive Immunology

Année:

2002

Langue:

english

Fichier:

PDF, 104 KB

english, 2002

11

The enlargement of the hormone immune deprivation concept to the blocking of TGFα-autocrine loop: EGFR signaling inhibition

Aillette Mulet, Greta Garrido, Anabel Álvarez, Tamara Menéndez, Frank-D Böhmer, Rolando Pérez, Luis Enrique Fernández

Journal:

Cancer Immunology, Immunotherapy

Année:

2006

Langue:

english

Fichier:

PDF, 438 KB

english, 2006

12

Complex formation of the laminin-5 γ2 chain and large unspliced tenascin-C in oral squamous cell carcinoma in vitro and in situ: implications for sequential modulation of extracellular matrix in the invasive tumor front

Marcus Franz, Torsten Hansen, Petra Richter, Laura Borsi, Frank-D. Böhmer, Peter Hyckel, Peter Schleier, Detlef Katenkamp, Luciano Zardi, Hartwig Kosmehl, Alexander Berndt

Journal:

Histochemistry and Cell Biology

Année:

2006

Langue:

english

Fichier:

PDF, 528 KB

english, 2006

13

Expression of the transmembrane protein tyrosine phosphatase RPTPα in human oral squamous cell carcinoma

A. Berndt, Xinmei Luo, Frank-D. Böhmer, Hartwig Kosmehl

Journal:

Histochemistry and Cell Biology

Année:

1999

Langue:

english

Fichier:

PDF, 546 KB

english, 1999

14

PDGF receptor kinase blocker AG1295 attenuates interstitial fibrosis in rat kidney after unilateral obstruction

Dirk Ludewig, Hartwig Kosmehl, Manfred Sommer, Frank-D. Böhmer, Günter Stein

Journal:

Cell and Tissue Research

Année:

2000

Langue:

english

Fichier:

PDF, 941 KB

english, 2000

15

Pyrrolo[3,4-c]-β-carboline-diones as a novel class of inhibitors of the platelet-derived growth factor receptor kinase

Steffen Teller, Stella Eluwa, Markus Koller, Andrea Uecker, Thomas Beckers, Silke Baasner, Frank-D. Böhmer, Siavosh Mahboobi

Journal:

European Journal of Medicinal Chemistry

Année:

2000

Langue:

english

Fichier:

PDF, 1.18 MB

english, 2000

16

A substrate peptide for the FLT3 receptor tyrosine kinase

Frank-D. Böhmer, Andrea Uecker

Journal:

British Journal of Haematology

Année:

2009

Langue:

english

Fichier:

PDF, 190 KB

english, 2009

17

Protein tyrosine phosphatases: regulatory mechanisms

Jeroen den Hertog, Arne Östman, Frank-D. Böhmer

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 414 KB

english, 2008

18

Calpain-mediated degradation of reversibly oxidized protein-tyrosine phosphatase 1B

Antje Trümpler, Bernhard Schlott, Peter Herrlich, Peter A. Greer, Frank-D. Böhmer

Journal:

Année:

2009

Langue:

english

Fichier:

PDF, 592 KB

english, 2009

19

Loss of the Protein-Tyrosine Phosphatase DEP-1/PTPRJ Drives Meningioma Cell Motility

Astrid Petermann, Daniela Haase, Andrea Wetzel, Kamal K. Balavenkatraman, Tencho Tenev, Karl-Heinz Gührs, Sabrina Friedrich, Makoto Nakamura, Christian Mawrin, Frank-D. Böhmer

Journal:

Brain Pathology

Année:

2011

Langue:

english

Fichier:

PDF, 1.31 MB

english, 2011

20

Opinion: Transactivation joins multiple tracks to the ERK/MAPK cascade

Wetzker, Reinhard, Böhmer, Frank-D.

Journal:

Nature Reviews Molecular Cell Biology

Année:

2003

Langue:

english

Fichier:

PDF, 1.67 MB

english, 2003

21

Tyr-c[D-Orn-Tyr(Bzl)-Pro-Gly]: a novel antiproliferative acting somatostatin receptor agonist with μ-opioid receptor-sensitizing properties

Jörg Stirnweiss, Bianka Hartrodt, Gisela Greksch, Uta Stürzebecher, Frank-D Böhmer, Klaus Neubert, Claus Liebmann

Journal:

British Journal of Pharmacology

Année:

2003

Langue:

english

Fichier:

PDF, 391 KB

english, 2003

22

UVA inactivates protein tyrosine phosphatases by calpain-mediated degradation

Gulati, Pawan, Markova, Boyka, Göttlicher, Martin, Böhmer, Frank-D, Herrlich, Peter A

Journal:

Année:

2004

Langue:

english

Fichier:

PDF, 291 KB

english, 2004

23

Corrigendum: UVA inactivates protein tyrosine phosphatases by calpain-mediated degradation

Gulati, Pawan, Markova, Boyka, Göttlicher, Martin, Böhmer, Frank-D., Herrlich, Peter A.

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 73 KB

english, 2005

24

The transmembrane protein tyrosine phosphatase RPTPσ modulates signaling of the epidermal growth factor receptor in A431 cells

Pestana, Eduardo Suárez, Tenev, Tencho, Groß, Steffen, Stoyanov, Borislav, Ogata, Masato, Böhmer, Frank-D

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 930 KB

english, 1999

25

The protein-tyrosine phosphatase DEP-1 modulates growth factor-stimulated cell migration and cell–matrix adhesion

Jandt, Enrico, Denner, Karsten, Kovalenko, Marina, Östman, Arne, Böhmer, Frank-D

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 506 KB

english, 2003

26

Redox Regulation in Mammalian Signal Transduction

Pawan Gulati, Peter-Christian Klöhn, Harald Krug, Martin Göttlicher, Boyka Markova, Frank-D. Böhmer, Peter Herrlich

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 123 KB

english, 2001

27

Tumorzellen — Vehikel mit defekten Bremsen

Müller, Jörg P., Petermann, Astrid, Mawrin, Christian, Böhmer, Frank-D.

Journal:

Année:

2012

Langue:

german

Fichier:

PDF, 376 KB

german, 2012

28

Oxidation sensitivity of the catalytic cysteine of the protein-tyrosine phosphatases SHP-1 and SHP-2

Irene Weibrecht, Sylvia-Annette Böhmer, Markus Dagnell, Kai Kappert, Arne Östman, Frank-D. Böhmer

Journal:

Free Radical Biology and Medicine

Année:

2007

Langue:

english

Fichier:

PDF, 1.04 MB

english, 2007

29

Modulation of xenobiotic metabolising enzymes by anticarcinogens—focus on glutathione S-transferases and their role as targets of dietary chemoprevention in colorectal carcinogenesis

Beatrice Pool-Zobel, Selvaraju Veeriah, Frank-D. Böhmer

Journal:

Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis

Année:

2005

Langue:

english

Fichier:

PDF, 487 KB

english, 2005

30

Stent-based release of a selective PDGF-receptor blocker from the bis-indolylmethanon class inhibits restenosis in the rabbit animal model

Enrico Jandt, Oliver Mutschke, Siavosh Mahboobi, Andrea Uecker, Ronny Platz, Alexander Berndt, Frank-D. Böhmer, Hans R. Figulla, Gerald S. Werner

Journal:

Vascular Pharmacology

Année:

2010

Langue:

english

Fichier:

PDF, 811 KB

english, 2010

31

Regulation of receptor tyrosine kinase signaling by protein tyrosine phosphatases

Arne Östman, Frank-D Böhmer

Journal:

Trends in Cell Biology

Année:

2001

Langue:

english

Fichier:

PDF, 193 KB

english, 2001

32

Perinuclear localization of the protein-tyrosine phosphatase SHP-1 and inhibition of epidermal growth factor-stimulated STAT1/3 activation in A431 cells

Tencho Tenev, Sylvia-Annette Böhmer, Roland Kaufmann, Steffen Frese, Thomas Bittorf, Thomas Beckers, Frank-D. Böhmer

Journal:

European Journal of Cell Biology

Année:

2000

Langue:

english

Fichier:

PDF, 268 KB

english, 2000

33

Purification and characterization of the Ca2+-ATPase of plasma membranes from Ehrlich ascites mammary carcinoma cells

Reinhard Wetzker, Frank-D. Böhmer, Reinhard Klinger, Elke Müller, Holger Hegewald, Michael Scheven, Richard Grosse

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Année:

1986

Langue:

english

Fichier:

PDF, 797 KB

english, 1986

34

Hydrodynamic and circular dichroic analysis of mammary-derived growth inhibitor (MDGI)

Joachim Behlke, Maren Mieth, Frank-D. Böhmer, Richard Grosse

Journal:

Biochemical and Biophysical Research Communications

Année:

1989

Langue:

english

Fichier:

PDF, 463 KB

english, 1989

35

The dephosphorylation characteristics of the receptors for epidermal growth factor and platelet-derived growth factor in Swiss 3T3 cell membranes suggest differential regulation of receptor signalling by endogenous protein-tyrosine phosphatases

Frank-D. Böhmer, Sylvia-Annette Böhmer, Carl-Henrik Heldin

Journal:

Année:

1993

Langue:

english

Fichier:

PDF, 504 KB

english, 1993

36

Activation of platelet-derived growth factor (PDGF) receptor dephosphorylation in intact Swiss 3T3 cells by elevators of intracellular Ca2+ and cAMP

Frank-D. Böhmer, S.-Annette Böhmer

Journal:

Année:

1996

Langue:

english

Fichier:

PDF, 418 KB

english, 1996

37

Antibodies against mammary derived growth inhibitor (MDGI) react with a fibroblast growth inhibitor and with heart fatty acid binding protein

Frank-D. Böhmer, Quan Sunt, Maren Pepperle, Thomas Muller, Ulf Eriksson, John L. Wang, Richard Grosse

Journal:

Biochemical and Biophysical Research Communications

Année:

1987

Langue:

english

Fichier:

PDF, 811 KB

english, 1987

38

PDGF receptor kinase blocker AG1295 attenuates interstitial fibrosis in rat kidney after unilateral obstruction

Dirk Ludewig, Hartwig Kosmehl, Manfred Sommer, Frank-D. Böhmer, Günter Stein

Journal:

Cell and Tissue Research

Année:

2000

Langue:

english

Fichier:

PDF, 941 KB

english, 2000

39

Synthetic 2-Aroylindole Derivatives as a New Class of Potent Tubulin-Inhibitory, Antimitotic Agents ‖

Mahboobi, Siavosh, Pongratz, Herwig, Hufsky, Harald, Hockemeyer, Jörg, Frieser, Markus, Lyssenko, Alexei, Paper, Dietrich H., Bürgermeister, Jutta, Böhmer, Frank-D., Fiebig, Heinz-Herbert, Burger, Ang

Journal:

Journal of Medicinal Chemistry

Année:

2001

Langue:

english

Fichier:

PDF, 370 KB

english, 2001

40

Specific neutralizing antiserum against a polypeptide growth inhibitor for mammary cells purified from bovine mammary gland

Böhmer, Frank-D., Lehmann, Wolfram, Noll, Franz, Samtleben, Rainer, Langen, Peter, Grosse, Richard

Journal:

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

Année:

1985

Langue:

english

Fichier:

PDF, 824 KB

english, 1985

41

Identification of Protein Tyrosine Phosphatases Associating with the PDGF Receptor †

Markova, Boyka, Herrlich, Peter, Rönnstrand, Lars, Böhmer, Frank-D.

Journal:

Année:

2003

Langue:

english

Fichier:

PDF, 175 KB

english, 2003

42

Binding of Phosphatidic Acid to the Protein-Tyrosine Phosphatase SHP-1 as a Basis for Activity Modulation †

Frank, Carsten, Keilhack, Heike, Opitz, Frank, Zschörnig, Olaf, Böhmer, Frank-D.

Journal:

Année:

1999

Langue:

english

Fichier:

PDF, 136 KB

english, 1999

43

Protein tyrosine phosphatases as wardens of STAT signaling

Böhmer, Frank-D, Friedrich, Karlheinz

Journal:

Année:

2014

Langue:

english

Fichier:

PDF, 536 KB

english, 2014

44

Proteinase-activated receptor 1- and 4-promoted migration of Hep3B hepatocellular carcinoma cells depends on ROS formation and RTK transactivation

Mußbach, Franziska, Henklein, Petra, Westermann, Martin, Settmacher, Utz, Böhmer, Frank-D., Kaufmann, Roland

Journal:

Journal of Cancer Research and Clinical Oncology

Année:

2015

Langue:

english

Fichier:

PDF, 2.27 MB

english, 2015

45

Deficiency of the protein-tyrosine phosphatase DEP-1/PTPRJ promotes matrix metalloproteinase-9 expression in meningioma cells

Petermann, Astrid, Stampnik, Yvonn, Cui, Yan, Morrison, Helen, Pachow, Doreen, Kliese, Nadine, Mawrin, Christian, Böhmer, Frank-D.

Journal:

Journal of Neuro-Oncology

Année:

2015

Langue:

english

Fichier:

PDF, 4.40 MB

english, 2015

46

High REDOX RESPONSIVE TRANSCRIPTION FACTOR1 Levels Result in Accumulation of Reactive Oxygen Species in Arabidopsis thaliana Shoots and Roots

Matsuo, Mitsuhiro, Johnson, Joy Michal, Hieno, Ayaka, Tokizawa, Mutsutomo, Nomoto, Mika, Tada, Yasuomi, Godfrey, Rinesh, Obokata, Junichi, Sherameti, Irena, Yamamoto, Yoshiharu Y., Böhmer, Frank-D., O

Journal:

Molecular Plant

Année:

2015

Langue:

english

Fichier:

PDF, 3.26 MB

english, 2015

47

Knockout of Density-Enhanced Phosphatase-1 Impairs Cerebrovascular Reserve Capacity in an Arteriogenesis Model in Mice

Hackbusch, Daniel, Dülsner, André, Gatzke, Nora, Krüger, Janine, Hillmeister, Philipp, Nagorka, Stephanie, Blaschke, Florian, Ritter, Zully, Thöne-Reineke, Christa, Böhmer, Frank-D., Buschmann, Ivo, K

Journal:

BioMed Research International

Année:

2013

Langue:

english

Fichier:

PDF, 2.76 MB

english, 2013

48

Chimeric tyrosine kinase-HDAC inhibitors as antiproliferative agents

Uecker, Andrea, Sicker, Marit, Beckers, Thomas, Mahboobi, Siavosh, Hägerstrand, Daniel, Östman, Arne, Böhmer, Frank-D.

Journal:

Anti-Cancer Drugs

Année:

2010

Langue:

english

Fichier:

PDF, 252 KB

english, 2010

49

NOX-driven ROS formation in cell transformation of FLT3-ITD positive AML

Jayavelu, Ashok Kumar, Moloney, Jennifer N., Böhmer, Frank-D., Cotter, Thomas G.

Journal:

Experimental Hematology

Année:

2016

Langue:

english

Fichier:

PDF, 879 KB

english, 2016

50

The protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase

Schneble, Nadine, Müller, Julia, Kliche, Stefanie, Bauer, Reinhard, Wetzker, Reinhard, Böhmer, Frank-D., Wang, Zhao-Qi, Müller, Jörg P.

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 743 KB

english, 2016